He has served as President, Nutrition Society of Canada and Chair, Nutrition Task Force (Heart & Stroke Foundation of Ontario). He has authored over 200 papers in scientific journals (medical, nutrition, other) in addition to various book chapters and conference proceedings. His research program is focused on dietary omega-3 fatty acids (DHA plus EPA) from fish/fish oils and resulting nutraceutical supplementation plus functional foods for human health and the roles for DHA/EPA in supporting optimal cognitive performance , visual acuity , and other health outcomes throughout the life cycle plus improving the prevention/management of cardiovascular disease risk factors/events and other chronic disorders (inflammatory conditions incl. arthritis and dry eye syndrome, certain cancers , asthma, mental deteriorations, others).
As well, he has been active in the evaluation of nutraceuticals and agri-foods for improving human health, disease prevention and management, and their potential for considerable cost-savings to the healthcare system. Dr. Holub has had active collaborative research with clinical groups in various Canadian medical schools, the Mayo Clinic in the United States, Japan, Greenland, Turkey, and the nutritional supplement plus agri-food sectors. He has given over 450 invited off-campus lectures in over 20 countries.